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Recent evidence highlights GLP-1RAs as a promising adjunctive therapy in critical conditions due to their protective effects: they improve endothelial function, reduce ischemiareperfusion injury, and regulate autonomic tone in the cardiovascular system
FDA-approved GLP-1 injections produce 14.9% to 20.9% body weight loss in rigorous clinical trials involving thousands of patients
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This creates a vicious, self-perpetuating cycle: mitochondrial dysfunction causes oxidative stress, and that oxidative stress causes further mitochondrial destruction
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