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Side effects were dose-dependent and transient

129 Further, the onset age 130 and duration of diabetes mellitus 131 may have some influence on synaptic plasticity

TAAR1 & Activation of NET/DAT/SERT Reverse Transport: Nature's Homeostatic Safety Valve Under baseline physiological conditions, catecholamines (like dopamine and norepinephrine) are kept sequestered at extremely low levels in the presynaptic cytoplasm (representing only ~3% of the total terminal contents), with the vast majority safely packaged in acidic storage vesicles (Hussain et al., 2023)

Peptide stability in gastric juice is documented - research confirms activity via subcutaneous and oral routes