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In this clinical trial with 20 women, oral supplementation with Pycnogenol was shown to significantly lower UV-induced expression of the pigment synthesizing enzymes TRP1 by 75%, tyrosinase by 51%, MITF by 67% and MART-1 by 67%

There are many causes of EDS, such as obstructive sleep apnea, sleep deprivation, depression, circadian rhythm disorders, and more

doi: 10.3389/fendo.2020.608733 Received 21 September 2020 Accepted 13 November 2020 Published 14 December 2020 Volume 11 - 2020 Edited by Marian Elizabeth Ludgate, Cardiff University, United Kingdom Reviewed by Utta Berchner-Pfannschmidt, Essen University Hospital, Germany