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Although mild liver enzyme elevations were noted, they were deemed manageable and consistent with underlying liver sensitivities common in Werner syndrome

One frequently discussed strategy involves a "quarter-dose" approach, where patients begin with approximately 0.625 mg (one-quarter of the 2.5 mg starting dose) and gradually increase over an extended period

(You may also see the term metabolic dysfunction-associated steatotic liver disease, or MASLD, used in newer literature, though NICE guidance currently refers to NAFLD.) Additionally, NAC possesses direct antioxidant properties and may help modulate inflammatory pathways within the liver

Oxidative and Nitrosative Stress and Immune-Inflammatory Pathways in Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)