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Non-motor symptoms: the hidden burden Gastrointestinal dysfunction and the gut-brain axis PD may originate in the gut before manifesting in the central nervous system (CNS) through the formation of alpha-synuclein aggregates within the visceral nervous system

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Functionally, overexpression of GSTM3 could significantly inhibit cell proliferation by delaying the G0/G1 transition, whereas the opposite results were found in the GSTM3 downregulation group