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In vivo studies conducted to assess the cardiotoxicity induced by doxorubicin and omega-3 in rats demonstrated that supplementation with omega-3 fatty acids reduced levels of malondialdehyde and enhanced the activity of antioxidant enzymes, including glutathione peroxidase and superoxide dismutase [134136]

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These findings indicate that G/D-CuP may significantly promote angiogenesis, as evidenced by increased CD31 expression during the initial stages of wound healing