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144,145 Mechanistically, TMAO may mediate the occurrence and development of stroke by promoting endothelial dysfunction, 7 inflammatory response, 146 oxidative stress, and lipid metabolism disorders

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The link between OS and DNA damage was further suggested by elevated measurements of the respective biomarkers by Samarawickrema et al (2008), who studied the effects of low-grade long-term exposure to environmental and occupational OPCs [10]