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Eligibility depends on the specific medication, body mass index, weight-related medical conditions, treatment history, contraindications, pregnancy status and other individual factors

Weekly dosing schedules have also improved adherence compared to older daily regimens

Potential areas of expansion include: Cardiovascular outcomes: A dedicated CVOT, if not already required as a post-marketing commitment, would evaluate whether orforglipron reduces MACE in patients with established cardiovascular disease or high cardiovascular risk, following the precedent set by the SELECT trial for semaglutide