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10.1146/ANNUREV-PHARMTOX-011112-140320 122 ManczakM.AnekondaT

Other mechanisms These include, among others, changes in the intestinal microbiota, in the glucose and insulin gradient of the porto-systemic axis, and in the action of GLP-1 on vagal afferents, as well as a reduction in endogenous glucose production12, and an increase in bile salts and intestinal glucose absorption due to increased expression of sodium-glucose cotransporter type 1 (SGLT1)7,1315

Additionally, in smokers who largely have higher oxidative stress than non-smokers, PYC supplementation (50 mg/day) reduced plasma levels of reactive oxidative species (derivatives of the reactive oxygen metabolites test) and increased antioxidant potential (biological antioxidant potential test) (Belcaro et al., 2013)

the specific delivery method depends on the provider's clinical recommendation following intake review