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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)
[Journal of Pharmacology and Experimental Therapeutics, 2000, vol
S2CID 25209863
The impact of curcumin on these enzymes that modify DNA and histones could depend not only on the concentration of this bioactive phytochemical, it is also important to take into account the cell model used
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