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Semaglutide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Understanding the medication's documented side effect profilepredominantly gastrointestinal symptomsand recognizing when lymph node swelling requires medical evaluation helps patients and clinicians distinguish medication-related effects from unrelated conditions requiring investigation