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Cancer cells produce high levels of endogenous antioxidant enzymes that neutralize FR, seeking to compensate for intracellular ROS levels, and this mechanism facilitates the survival of neoplastic cells [175]

In a recent Cell paper, Wang and colleagues discovered a new type of cell death caused by contact between mitochondria and the plasma membrane, which they name mitoxyperiosis

Start conservatively at 0.25 mg daily for the first week to assess tolerance before increasing to 0.5 mg if needed