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Increased superoxide production was observed in all layers of the vascular wall, namely the endothelium, media and adventitia, 14 and may also increase vasoconstrictor tone via stimulation of the expression of endothelin-1 in the smooth muscle and endothelial cell layer

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More broadly, alterations in lipid metabolism, such as those mediated by short-chain fatty acids (e.g., butyric acid), can influence cell death pathways by modulating the expression of copper-related genes [127]