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Among these overlap genes, BLM downregulated the expression of Sele, Cytl1, Dpysl5, Gc, Nrgn genes, which are mainly involved in cell adhesion, 25 inflammatory response, 26 nerve conduction, 27 signal transduction, 28 material transport and metabolism, 29 , 30 and FOXO4DRI attenuated the depression of these gene expressions (Figure S3B)