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Besides diabetes and high blood pressure, the following additional health conditions may also contribute to CKD 1 : Cardiovascular disease Systemic or kidney infections Immune system conditions (eg, lupus) Inflammation of the glomeruli (tiny filters) in the kidneys Inherited kidney disease (eg, polycystic kidney disease) Congenital defects (eg, kidney malformation, urinary tract obstruction) Medications and toxins (eg, prolonged medication, chemical, or street drug exposure) Factors such as those described above and various others can contribute to the decline in kidney function characteristic of CKD

Glutathione plays a pivotal role in neutralising reactive oxygen species such as free radicals and peroxides, thus protecting the cells from oxidative stress

Each route has a different evidence base, and non-injectable routes should be treated as historical or limited-evidence context rather than a protocol recommendation

[23] The bioavailability of oral glutathione in humans is a controversial subject