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Absolute contraindications for doxycycline include the following: Age below 8 years Pregnancy or lactation Hypersensitivity to any of the tetracyclines Concomitant use with penicillin, isotretinoin, or multivalent cations Relative contraindications for doxycycline include the following: Exposure to direct sunlight or ultraviolet light Recent colitis caused by antibiotic use History of yeast infections and/or lupus Patients with porphyria, systemic lupas erythematosus, diarrhea from C

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To compare continuous variables among groups, Students t test, Mann-Whitney U test and Friedman test were utilized