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**Distilled Water:** Essential for diluting and ensuring the purity of your mask, preventing contamination

Ma, X., Yinwang, E., Chai, X., Wang, F., Chen, Z., Wang, S., et al

Statements Data availability statement The mass spectrometry proteomics and phosphoproteomics data generated in this study are in the process of being deposited to the ProteomeXchange Consortium via the PRIDE partner repository

Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure