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In depression, it is hypothesized that the regulation of ACTH and cortisol secretory activity are altered, along with impaired corticosteroid receptor signaling (250,251)

The picture is complicated by several confounding factors: Weight loss itself is associated with improved mood and reduced depressive symptoms in many individuals Better glycaemic control may enhance overall wellbeing and reduce diabetes-related distress Selection bias may exist, as patients with severe mental health conditions might be less likely to be prescribed these medications initially Currently, there is no official indication for GLP-1 agonists in treating depression, and the MHRA has not licensed these medications for mental health conditions

However, if your GLP1R gene carries loss-of-function variants, your maximum natural output may always be insufficient, making semaglutide therapy a more reliable solution

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