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In chronically stimulated T-cells ( e.g ., in the tumor or persistent antigen context), researchers found a progressive loss of PGC-1 and other metabolic regulators, resulting in small, fragmented, and dysfunctional mitochondria in exhausted T-cells (68)

At the highest dose, 16% of participants taking the triple agonist had to discontinue the drug due to gastrointestinal side-effects