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Methotrexate nausea and tirzepatide nausea could potentially compound each other, particularly during the early titration phase

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (under brand names Ozempic and Rybelsus) and chronic weight management (Wegovy)

This finding has been corroborated across different preclinical models, where impaired BCAA catabolic activities and increased BCAA levels were observed in the several preclinical HFpEF models 93,94

73 This was a multicentre observational cohort study from 170 hospitals across the US that investigated the effects of GLP-1 RAs on clinical outcomes, a composite of HF hospitalisation and all-cause mortality, in 1,024 obese HFpEF patients compared with 796 controls receiving dipeptidyl peptidase inhibitor/sulphonylurea therapy