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Interestingly, our analysis revealed that the unfavorable impact of lixisenatide on MI rates was reversed upon the removal of the ELIXA trial [40] in the sensitivity analysis (NNTB: 569, 95%CI: NNTB 252 to to NNTH 10)

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Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action Melanotan II binds to melanocortin receptor subtypes (MC1R-MC5R) , mimicking the activity of endogenous -MSH

Genetic manipulation (FDX1 knockout/overexpression) in vitro could clarify its regulatory hierarchy and enable mitochondrial functional analyses