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Addressing those here

Some researchers prefer morning administration, reasoning that any transient nausea will occur during active hours when it is easier to manage

Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)