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In a double blind, dosing range study, the group that used topic malassezin twice a day for 8 weeks had a 30.13% reduction in the severity of hyperpigmentation, compared with 16.67% in the placebo group

There is no good evidence for this, and it is worth being cautious about that framing

Creatine and tirzepatide interaction is a common concern for patients using tirzepatide (Mounjaro, Zepbound) for diabetes or weight management while considering creatine supplementation for muscle preservation