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But when you slow gastric emptying with a compound that lasts seven days instead of seven minutes, you get more pronounced and longer-lasting effects on digestion

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This mechanism has been demonstrated in animal models, including MC1R-defective mice, where topical forskolin application led to persistent epidermal melanization

"Cannabis is widely used, but its long-term effects on health remain poorly characterized," said Sandra Sanchez-Roige, Ph.D., associate professor of psychiatry at UC San Diego School of Medicine and senior author of the study