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A newer iteration of TTOAD2, termed TTP273, is in clinical trials, and early, unpublished results suggest it is highly effective for blood glucose control ( Another oral small molecule GLP1 receptor agonist (PF06882961) has also been recently described which shares a similar mode of GLP1 receptor binding with LY3502970 but, interestingly, shows only a minor degree of bias in favour of cAMP over arrestin recruitment (Griffith et al., 2020
The molecule contains one methionine residue (Met-27) susceptible to oxidation, requiring inert atmosphere handling for long-term storage [1][5]
Gizi A, Papassotiriou I, Apostolakou F, et al
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