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Importantly, extracellular glutamate levels are tightly regulated, as their overabundance at synapses are inked to glutamate-induced excitotoxicity, a condition caused by elevated extracellular brain glutamate concentrations combined with excessive glutamatergic stimulation, resulting in surges in intracellular calcium levels and the initiation of neurotoxic signaling pathways, that are implicated in several neurological pathologies, including neurodegenerative disorders 6,8

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Role of autophagy in cancer

To evaluate differences among multiple groups, one-way analysis of variance (ANOVA) was conducted, which allowed for the comparison of means across the different experimental conditions