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Metabolic studies showed that AOD9604-treated animals had increased lipolytic rates measured in isolated adipocytes, elevated circulating free fatty acid levels, and enhanced fatty acid oxidation rates

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In mammals, the mtDNA encodes only 37 genes, of which 13 are subunits of the OXPHOS (complexes I, III, IV, and V), two are rRNA genes, and 22 are tRNA genes required for mitochondrial protein synthesis