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Are GLP-1 medications safe to use long-term

Individuals with a history of heart attacks, who then take nitric oxide, not only face the risk of recurring heart attacks but also gastrointestinal problems

The cholesterol hypothesis for heart disease dates back to the early 1900s when Russian physician Nikolay Anichkov demonstrated that feeding rabbits a high cholesterol diet led to the fatty deposits in coronary arteries that cause heart disease

Certainly, human patients with T2DM display a blunted incretin effect of GLP-1, and defects in meal-induced intestinal GLP-1 secretion (91), suggesting that the paracrine action of alpha-cell-derived GLP-1 may be necessary to combat this diminished peripheral incretin action of gut-derived GLP-1