Current trends and challenges in the clinical translation of nanoparticulate nanomedicines: pathways for translational development and commercialization
Contributing factors include: reduced nutritional intake (proteins, essential amino acids, competition between amino acid transporters, vitamin insufficiency [riboflavin: GSSG reductase, nicotinic acid: NADPH, pyridoxine (B 6 ): SAMe pathway], mitochondrial dysfunction: ATP deficiency, down regulation SAMe synthase, oxidation of SAMe pathway enzymes, enhanced GSH utilization: conjugation reactions (toxins, drugs), and overwhelming oxidative challenge
Research suggests glutathione supplementation may help improve insulin resistance, reduce cell damage in fatty liver disease, and increase mobility for people with peripheral artery disease
The individuals labs reveal any deficiencies that need to be accounted for during glutathione supplementation, such as deficiencies in B vitamins and other cofactors that GSH needs to optimize its effectiveness