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Regular monitoring of inflammatory markers, disease activity scores, and functional status remains essential regardless of concurrent GLP-1 use

Intranasal delivery is of growing interest in pharmacokinetic research because it circumvents first-pass metabolism, making it ideal for exploring receptor pathway interactions in a more direct and rapid fashion

The observed interactions between the ECD and ECL1/3 in the inactive GLP-1R structure presented here agree with previous studies suggesting that the ECD stabilized an inactive state of the glucagon receptor through interactions with ECL1 and ECL3 20