alternatives to tirzepatide for weight loss A 72-week trial compared the two leading GLP-1 medications in adults with obesity (no diabetes). The results: ✓ Tirzepatide: 20.2% ✓ Semaglutide: 13.7% weight loss But weight loss isn't the Mounjaro (Tirzepatide) for Medical Weight

Front Biosci (Schol Ed) 4:722748 Mats JM, Segura JA, Campos-Sandoval JA et al (2009) Glutamine homeostasis and mitochondrial dynamics

Treating hypothyroidism or hormone therapy with testosterone or estrogen can help

One large 2019 study tells a different story

If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below