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For patients with bi-allelic mutations in POMC , LEPR , or MC4R [45] , bariatric surgery achieved only limited long-term weight loss, with all patients experiencing significant weight regain after initial weight reduction

Dosing Epithalon Capsules Because orally delivered epithalon is a new approach, there is no scientific dosing protocol for oral epithalon capsules

Insulin sensitivity, assessed by the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), improved with the administration of CT-388, particularly in the highest dosed cohort