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Activity changes: Some experience fatigue or reduced energy on GLP-1s, leading to less physical activity and resistance training that would otherwise preserve muscle

3.6.3.2 Microbial metabolites A substantial body of research highlights the role of gut microbiota and their metabolites, particularly SCFAs, in regulating metabolic, endocrine, and immune functions, with emerging evidence pointing to their involvement in neuro-immunoendocrine pathways through the MGBA (Silva et al., 2020)