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The medication does not permanently reset metabolic function or appetite regulation, which is why a structured approach to discontinuation and long-term lifestyle modification is critical for maintaining weight loss achievements

Animal studies in diet-induced obesity models show tesofensine treatment produces selective reduction in adiposity with improvements in insulin sensitivity, reductions in plasma lipids, and decreased accumulation of abdominal and subcutaneous fat mass

[28] Tightly bound cofactors are, in general, regenerated during the same reaction cycle, while loosely bound cofactors can be regenerated in a subsequent reaction catalyzed by a different enzyme

Hypersensitivity, such as hives (urticaria) Respiratory Side Effects (particularly when used inhaled/nebulized): Chest tightness Bronchoconstriction (airway narrowing) Irritation of the bronchi or the trachea