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We thank Shigetoshi Koga (Kurume University) for laboratory animal care

Thatikonda, V, Lyu, H, Jurado, S, Kostyrko, K, Bristow, C, Albrecht, C, Alpar, D, Arnhof, H, Bergner, O, Bosch, K, Feng, N, Gao, S, Gerlach, D, Gmachl, M, Hinkel, M, Lieb, S, Jeschko, A, Machado, AA, Madensky, T, Marszalek, ED, Mahendra, M, Melo-Zainzinger, G, Molkentine, JM, Jaeger, PA, Peng, D, Schenk, RL, Sorokin, A, Strauss, S, Trapani, F, Kopetz, S , Vellano, CP, Petronczki, M, Kraut, N, Heffernan, TP, Marszalek, JR, Pearson, M, Waizenegger, IC, Hofmann, MH

CONCLUSION AND FUTURE DIRECTIONS Gut microbiota metabolites play crucial roles in maintaining the functional balance of the microbiotagutbrain axis, thus offering neuroprotection and promoting regeneration of nervous tissue