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For some, a single, larger weekly dose might lead to intense side effects in the initial days post-injection, followed by a waning of effects towards the end of the week

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doi: 10.1016/j.cell.2021.06.019 286

However, they occurred naturally, without testosterone replacement therapy (TRT), and likely reflect the body recovering its normal hormone production as weight and insulin resistance improved. The study highlights the need for men already on testosterone therapies to closely monitor their levels after starting weight loss medications, Portillo said