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Severe abdominal pain, particularly pain accompanied by vomiting that won't stop, may signal acute pancreatitisa rare but serious inflammatory condition of the pancreas

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In addition to mTORC signaling, CUL5 promotes the ubiquitination and degradation of p62 by forming a complex with ASB6a protein containing a C-terminal SOCS box motifthereby enhancing autophagy in hepatocellular carcinoma (129)