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IGF-1 LR3 is a long-acting full IGF-1 receptor agonist driving systemic IGF-1 signalling

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Risk is highest during the initial titration phase and subsequent dose increases, particularly in vulnerable populations such as older adults or those with pre-existing conditions

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Lau DCW, Batterham RL, le Roux CW

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When any of these are deficient, the threshold for abnormal electrical firing is lowered

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