questions to ask before starting glp 1 7 GLP-1 Your Doctor 5 QUESTIONS TO ASK YOUR

Each works through a different mechanism, and the evidence levels are very different

Premixed regimen Split mix regimen Basal bolus regime (multidose) Bedtime dosing alone (NPH/Lente/Glargine) Infusion Premixed insulin Premixed(30/70): Regular: 30 % NPH : 70% Premixed (50/50): Regular 50% NPH 50% Premixed Analogs Biphasic insulin aspart (30/70) 30% : Aspart 70% : protaminated aspart Insulin Therapy Regimens Usual starting dose: 0.5-1.0 unit/kg/day Premixed insulin Dose adjustment: The fasting sugar depends on the night dose of insulin The post breakfast sugar depends on the morning dose of insulin Rough calculation increase the insulin by one unit to reduce the sugars by 25mg/dl Self Monitoring is crucial Glucometers At least 6-8 times a week ideally Premixed insulin Advantages more accurate dosing lesser injections Pen devices administer premixedforms Disadvantages Fine tuning may not be possible Strict meal pattern Nocturnal hypoglycemia May need diet changes for insulin rather than insulin changes fordiet Split-mixed insulin Common combinations: Short acting plus intermediate acting in a syringe:- Regular + NPH How to adjust insulin doses in a split mix Regular meal Regular NPH Increase regular insulin How to adjust insulin doses in a split mix Regular meal Regular NPH Reduce regular insulin How to adjust insulin doses in a split mix

In chronic conditions such as type 2 diabetes and obesity, treatments that fit into everyday routines may be easier to stay on

Newer drugs, such as tirzepatide, a dual GLP-1, and GIP receptor agonist, are quickly gaining traction and demonstrating encouraging outcomes in clinical trials for weight management. Other popular diabetes medications include metformin, gliflozins (Farxiga, Jardiance), and sulfonylureas (Glucotrol, Amaryl)