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Butyrate can also downregulate the expression of pro-inflammatory factors such as TNF- by inhibiting NF-B nuclear translocation and the degradation of inhibitor of nuclear factor B alpha (IkB), thereby exerting mucosal anti-inflammatory effects (93)

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IL-10 is an anti-inflammatory cytokine that negatively regulates the immune response, reduces inflammation, and protects against neuroinflammatory processes associated with neurodegenerative diseases (reviewed in: 38 )