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Serious Indicators of Vitamin B-12 Deficiency Severe vitamin B12 deficiency can cause signs and symptoms such as Yellow skin Weak muscles Numb or tingly hands or feet Trouble walking Severe joint pain Increasing shortness of breath Weight loss Irritability Lack of smell and taste sensations Memory loss Paranoia Delusions Deep depression What Does B12 Fatigue Feel Like

Supplementary information ESM 1 (download DOCX (DOCX 1210 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

I'm more interested in the FGF21s in F4, where I expect both of these (effectively anti-steatotics) to have lower efficacy.

For patients whose sera tested positive in the screening immunoassay, an in vitro biological assay was performed to detect neutralizing antibodies