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Description

The first GLP-1 receptor was cloned by Bernard Thorens (figure 31) in 1992 (Thorens)

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SAR441255 demonstrated superior weight loss compared to dual GLP-1/GCG agonists in animal models and did not exhibit major cardiovascular adverse effects in lean monkeys

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Preclinical data indicated that tirzepatide exhibited an affinity for GIPR equivalent to GIP binding, while its affinity for GLP-1R was approximately five times weaker compared to GLP-1 (63)

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Tirzepatide trials showed rates around 12-27% depending on the dose

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