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Randomized Trial Closes Chapter on Plasminogen Activator Alteplase in Large Thrombus STEMI PCI Oct 28, 2025 by Natalie Morrison, CRTonline.org The low-dose recombinant tissue plasminogen activator alteplase did not reduce 30-day major adverse cardiac events (MACE) in patients undergoing percutaneous coronary intervention (PCI) for ST-Segment elevation myocardial infarction (STEMI) and large thrombus burden in a randomized trial, closing the chapter on the potential treatment option

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GLP-1RA intervention was associated with a reduction in AG when compared to those given metformin or placebo (MD = 2.05

Metabolic adaptation occurs as the body adjusts to lower caloric intake, reducing resting energy expenditure