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The agents for treatment including the use of traditional anti-hyperglycemic agents (AHAs) such as metformin, insulin or pioglitazone, and reninangiotensinaldosterone system (RRAS) inhibitors like angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor blockers (ARBs)

Plaintiffs attribute severe health conditions such as gastroparesis, intense vomiting, and bowel obstruction to these medications

However, no clinical data supports more frequent than weekly administration, and most prescribers are reluctant to deviate from the FDA-approved schedule due to the unknown risk profile at elevated drug exposures

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