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When there is excessive accumulation of LIP in chondrocytes, the overloaded Fe 2+ catalyzes the explosive generation of ROS through the iron-dependent Fenton reaction (Yang et al., 2024)

Glutathione and hallmarks of aging: A study in older adults (n=48, aged 60-80) found that GlyNAC supplementation for 16 weeks improved several molecular hallmarks of aging, including mitophagy, nutrient sensing (reduced mTOR activation, increased AMPK signaling), inflammation (reduced NF-kB activation), and genomic instability (reduced 8-OHdG), alongside increased telomerase activity (Kumar et al., Aging, 2023) [31]

Once patients stop taking them, the weight loss effects often fade, and potential risks like bone loss, muscle reduction, and persistent nausea have raised concerns about their long-term safety

Krzastek SC, Farhi J, Gray M, Smith RP