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Participants taking retatrutide 4 mg, 9 mg, and 12 mg lost an average of 29.8 lbs (12.7%), 45.4 lbs (19.1%), and 49.6 lbs (20.8%), respectively, alongside A1C reductions of up to an average of 1.6%

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These results confirmed that HNF4 directly controls the transcription of these SAA metabolic enzymes in part through the identified consensus HNF4 binding sites on their promoters