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The top five, in bold, are the most important and necessary to establish a diagnosis: Many of these tests require specimens that are chilled by using a special centrifuge as the mast cell mediators are fleeting and degrade very quickly if not handled properly

Genome Res 27(8):1287-1299, 2017

This highlights the potential treatment role of targeting the NLRP3 pathway in managing cardiac complications associated with dysbiosis and LPS-induced inflammation