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A significantly decreased MDA level following riboflavin therapy has also been reported in experimental models of several other diseases such as acute lung injury (Reference Al-Harbi, Imam and Nadeem22) , hepatotoxicity (Reference Al-Harbi, Imam and Nadeem25,Reference Bashandy, Ebaid and Moussa26) , diabetes (Reference Alam, Iqbal and Naseem31) and cisplatin- (a chemotherapy medication) induced toxicities (Reference Naseem, Hassan and Alhazza28,Reference Salman and Naseem29)

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8-weeks aerobic exercise ameliorates cognitive deficit and mitigates ferroptosis triggered by iron overload in the prefrontal cortex of APPSwe/PSEN1dE9 mice through Xc-/GPx4 pathway