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Further studies revealed that GLC increases melanin production in melanocytes by three pathways, 1) activating activator protein-1 (AP-1) and CRE promoter to activate p42/44 MAPK signaling, 2) activating cAMP signaling, and 3) decreasing GSK3 phosphorylation while inducing CREB phosphorylation (Lee et al., 2005)

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Given that the degree of globe flattening and optic nerve head protrusion due to SANS has been correlated with an increase in optic nerve sheath volume [36], some authors have speculated that in microgravity, CSF sequesters within the narrow and septate optic nerve subarachnoid space in a mechanism akin to a one-way valve, leading to a compartment syndrome [64]

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