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This may be due to the fact that excessive growth signals can lead to the proliferation of unhealthy cells, including senescent and cancerous cells, in addition to healthy cells

This priming-dependent enhanced phosphorylation aligns with our in vivo post-translational modification analysis: S114 phosphorylation is consistently detectable, whereas downstream residues S117 and S120 remain elusive, likely due to the transient nature of their phosphorylation following S114 priming

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May 23, 2018